Continuous, hyperfractionated, accelerated radiotherapy (CHART)
نویسندگان
چکیده
منابع مشابه
Non-small cell lung cancer and CHART (continuous hyperfractionated accelerated radiotherapy)--where do we stand?
This paper reviews the use of hyperfractionated and/or accelerated radiation therapy in the curative treatment of non-small cell lung cancer, and explains the scientific rationale behind the development of these regimes. The indications, practicalities and economics of introducing them routinely are addressed. Novel radiotherapy techniques are further discussed in the context of current develop...
متن کاملContinuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial. CHART Steering Committee.
BACKGROUND Human tumour cells can proliferate rapidly, and giving radiotherapy in many small fractions may reduce long-term normal-tissue morbidity. In response to these observations, we developed the CHART (continuous hyperfractionated accelerated radiotherapy) regimen, which uses thirty-six small fractions of 1.5 Gy given three times per day, to give 54 Gy in only 12 consecutive days. We repo...
متن کاملThe rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer.
PURPOSE To demonstrate the feasibility of preoperative Hyperfractionated Accelerated RadioTherapy (preop-HART) in rectal cancer and to explain the rationales to switch from postoperative HART to preoperative HART. METHODS AND MATERIALS Fifty-two consecutive patients were introduced in successive Phase I trials since 1989. In trial 89-01, postoperative HART (48 Gy in 3 weeks) was applied in 20...
متن کاملAccelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx.
BACKGROUND The purpose of this study was to report the treatment outcome of a patient with nasopharyngeal small cell carcinoma. METHODS The patient received concurrent chemoradiotherapy (CRT). Chemotherapy consisted of 4 cycles of cisplatin and etoposide. Accelerated hyperfractionated radiotherapy (RT) was performed with a dose of 45 Gy in 30 fractions over 3 weeks for the nasopharynx and upp...
متن کاملHyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma.
PURPOSE With a view to improving the prognosis for patients with metastatic medulloblastoma, we tested the efficacy and toxicity of a hyperfractionated accelerated radiotherapy (HART) regimen delivered after intensive sequential chemotherapy. PATIENTS AND METHODS Between 1998 and 2007, 33 consecutive patients received postoperative methotrexate (8 g/m(2)), etoposide (2.4 g/m(2)), cyclophospha...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1989
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1989.64